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6. CONCLUSIONS
• Window of Implantation: inter-patient variability
• personalised WOI definition (ART/pET)
• Histologic markers combined with novel molecular markers
• Expression profiles in clinical use (pET)
• Secretome and Microbiome carry further potential
• Steroid hormones have strong impact on WOI
• Intracrinology: part of the endocrine control
• Intracrinology: offers insights and possibly markers in a personalised WOI determination
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7. Bibliography
• Brosens J, Verhoeven H, Campo R, Gianaroli L, Gordts S, Hazekamp J, Hagglund L, Mardesic T, Varila E, Zech J, et al. 2004 High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome. Hum Reprod 19 352-356.
• Casper RF & Yanushpolsky EH 2016 Optimal endometrial preparation for frozen embryo transfer cycles: window of implantation and progesterone support. Fertil Steril 105 867-872.
• Cheon JY, Mozersky J & Cook-Deegan R 2014 Variants of uncertain significance in BRCA: a harbinger of ethical and policy issues to come? Genome Med 6 121.
• Cornel KM, Krakstad C, Delvoux B, Xanthoulea S, Jori B, Bongers MY, Konings GF, Kooreman LF, Kruitwagen RF, Salvesen HB, et al. 2017 High mRNA levels of 17beta-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer. Mol Cell Endocrinol 442 51-57.
• Cornel KM, Kruitwagen RF, Delvoux B, Visconti L, Van de Vijver KK, Day JM, Van Gorp T, Hermans RJ, Dunselman GA & Romano A 2012 Overexpression of 17beta-Hydroxysteroid Dehydrogenase Type 1 Increases the Exposure of Endometrial Cancer to 17beta-Estradiol. J Clin Endocrinol Metab 97 E591-601.
• Das A, Mantena SR, Kannan A, Evans DB, Bagchi MK & Bagchi IC 2009 De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis. Proc Natl Acad Sci U S A 106 12542- 12547.
• Dassen H, Punyadeera C, Kamps R, Delvoux B, Van Langendonckt A, Donnez J, Husen B, Thole H, Dunselman G & Groothuis P 2007 Estrogen metabolizing enzymes in endometrium and endometriosis. Hum Reprod 22 3148-3158.
• Delvoux B, D'Hooghe T, Kyama C, Koskimies P, Hermans RJ, Dunselman GA & Romano A 2014 Inhibition of
type 1 17beta-hydroxysteroid dehydrogenase impairs the synthesis of 17beta-estradiol in endometriosis
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lesions. J Clin Endocrinol Metab 99 276-284.
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