Page 135 - PRECONGRESS COURSE 04

Regenerative Medicine in Reproductive Medicine
Asherman’s Syndrome Treatment: PRACTICE
(Prevention, Anticipation, Comprehensive Therapy, Timely Surveillance of subsequent Pregnancies, Investigation and Continous Education)
Endometrial Atrophy (<5mm)
Treatment:
• High doses of E2 Pentoxifylline 800mg/day + Vitamin E (1000 IU/day) during 6 months (Takasaki, 2010)
• Sildenafil 100mg vaginally (Takasaki, 2010) 6mg L-arginine daily (Acharya, 2009)
• Intrauterine perfusion of 300mg of G-CSG (Gleicher, 2011; Barad 2014)
CD133+
• Member of the cell surface glycoproteins family
• Excellent safety profile for CD133+ stem cell transplantation in phase I studies (Meregalli, 2008)
• Capacity to engraft and to differentiate into functional non- haematopoietic cell lineage (Rafii & Lyden, Nat Med 2003)
• Isolation system with CEE mark
• Long-term repopulation potential in SCID mice (Yang et al, 1997)
PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 135