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Human oocyte legacy and clinical implications
● Present day human assisted reproductive technologies (ARTs) draw upon COH that may compromise competencies
● The introduction of ICSI, egg and embryo cryopreservation, and extended embryo culture raise questions regarding processing of legacy components after fertilization
● A complex array of endocrine, paracrine, and juxtacrine signaling pathways executed prior to ovulation impose competencies that impact embryo development and implantation.
Clinical Implications
From Mol Hum Reprod. 2015 Jan;21(1):23‐30. Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role? Turner N, Robker RL. by permission of Oxford University Press
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