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Germ Cell Primordial Nest
Nest Breakdown
Inhibitors:TW
Foxl2 Nobox Estrogens
Primary
Transition Activation
Secondary
Developmental Competence
GDF9 BMP15
LH
Antral
Activation: TW SCF
bFGF BMP4 BMP 7 mTorc1 KL PI3K Insulin KGF
PDGF
GDNF
LIF
GDF9
LHX8, Sohl1/2
Repression: TW PTEN
Foxo3
AMH
TSC 1 / 2 KL
p27 Pre GC Foxl 2
SDF‐1 Estrogen Progesterone
Albertini, D.F. The Mammalian Oocyte. In, Knobil and Neill’s Physiology of Reproduction, Editors-in-Chief Tony M. Plant and Anthony J. Zeleznik, 4th edition doi.org/10.1016/B978-0 12-397175-3.00002-8
TW: Woodruff, 2009; K Liu, 2013; Matzuk LI, 2013;
Metabolic Symbiosis
● SharingMetabolismviagapjunctionsformostmetabolic substrates, amino acids, choline, uridine, cholesterol (but not folate (Baltz, Schultz, Eppig)
● Sharing “informative” molecules via unknown mechanisms including miRNAs (Robert, Sirard)
Sharing organelles (?) by direct exchange of cytoplasm, receptor‐mediated endocytosis, exosomes
Meiotic Resumption
